- Title
- Prevalence and risk of developing comorbid conditions in patients with chronic constipation
- Creator
- Mody, Reemy; Guérin, Annie; Fok, Beverly; Lasch, Karen L.; Zhou, Zhou; Wu, Eric Q.; Zhou, Wen; Talley, Nicholas J.
- Relation
- Takeda Pharmaceuticals International
- Relation
- Current Medical Research and Opinion Vol. 30, Issue 12, p. 2505-2513
- Publisher Link
- http://dx.doi.org/10.1185/03007995.2014.964854
- Publisher
- Informa Healthcare
- Resource Type
- journal article
- Date
- 2014
- Description
- Objective: To estimate the prevalence of gastrointestinal (GI) and non-GI comorbidities and the risk of incident comorbidities among patients with and without chronic constipation (CC). Research design and methods: Adults with CC were identified from a large retrospective US claims database. Each CC patient was matched 1:3 to CC-free patients by birth year, sex, and region of residence. Main outcome measures: Prevalence of GI and non-GI comorbidities was measured over a 1-year period. Relative risk of new comorbidities was also estimated among patients who were free of the studied comorbidity prior to the index date. Results: Mean age was 61.9 years; 33.3% of patients were male. The 1-year prevalence of GI comorbidities was significantly higher in CC (N = 28,854) vs. CC-free (N = 86,562) patients (all p<0.05). The risk of developing new GI conditions was also significantly higher in CC patients for all studied conditions except ulcerative colitis: megacolon (hazard ratio [95% confidence interval] HR [CI] = 11.96 [8.16–17.53]), intestinal impaction (10.56 [9.22–12.10]), volvulus (7.12 [5.42–9.35]), other specified functional intestinal disorders (6.67 [5.57–8.00]), and other unspecified functional disorders of intestine (4.60 [3.61–5.87]). Similarly, 1-year prevalence of non-GI comorbidities was higher in CC patients, as was the risk of developing new conditions: depression and mood disorder (HR [CI] = 1.84 [1.77–1.90]), neurological disorders (1.68 [1.62–1.74]), iron deficiency anemia (1.52 [1.47–1.57]), hypothyroidism (1.40 [1.34–1.46]), and peripheral vascular disorders (1.40 [1.34–1.46]). Limitations: An algorithm was used to define CC as there is no specific diagnosis code to identify CC. Conclusions: CC patients had significantly higher prevalence and were at increased risk of developing new GI and non-GI comorbidities than age-, gender- and region-matched CC-free patients. Future research is warranted to better understand these associations.
- Subject
- chronic constipation; comorbidities; prevalence
- Identifier
- http://hdl.handle.net/1959.13/1061122
- Identifier
- uon:16887
- Identifier
- ISSN:0300-7995
- Language
- eng
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